Clear cell odontogenic tumor--a new histologic variant with aggressive potential

Area of Science:

• Oral Pathology
• Oncology

Background:

• Describes a novel neoplasm of presumed odontogenic origin.
• Highlights the importance of accurate diagnosis for rare jaw tumors.

Observation:

• Three cases of a centrally located, expansile jaw tumor in women are presented.
• Clinical presentation included few symptoms, jaw enlargement, or mobile teeth.
• Radiographic findings revealed bone and tooth destruction with ill-defined margins.

Findings:

• Microscopic analysis showed uniform vacuolated and clear cells in sheets and islands.
• No amyloid deposition, calcification, or glandular differentiation was observed.
• One tumor recurred locally after 1.5 years, with no metastasis.

Implications:

• Suggests a locally aggressive odontogenic neoplasm.
• Warns of potential misdiagnosis as metastatic clear cell carcinoma (e.g., renal cell carcinoma).
• Emphasizes the need for specialized histopathological evaluation.