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Related Experiment Video

Updated: Sep 12, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

EHR-Based CDS Tools Supporting Long-Term Implementation of Pharmacogenomics.

Pedro J Caraballo¹, Jessica A Wright², Joseph A Sutton³

¹Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Studies in Health Technology and Informatics

|August 8, 2025

Summary

This summary is machine-generated.

Pharmacogenomics (PGx) improves prescribing. A multidisciplinary program implemented PGx-clinical decision support (CDS) for 45 drug-gene interactions in 42,000 patients, successfully triggering over 9,000 interventions.

Keywords:

Clinical decision support decision making electronic health record personalized medicine pharmacogenomics

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Published on: December 9, 2015

Area of Science:

Clinical Pharmacology
Genetics and Genomics
Health Informatics

Background:

Pharmacogenomics (PGx) offers potential to optimize drug prescribing.
Clinical decision support (CDS) systems can integrate PGx data into electronic health records.
Implementing PGx-CDS requires a multidisciplinary approach and robust infrastructure.

Purpose of the Study:

To describe the implementation and outcomes of a multidisciplinary pharmacogenomics clinical decision support (PGx-CDS) program.
To evaluate the impact of PGx-CDS on clinical practice at a large patient cohort.

Main Methods:

Development of a multidisciplinary program for PGx-CDS implementation starting in 2012.
Integration of PGx testing results for 45 drug-gene interactions.
System-wide implementation of PGx-CDS in electronic health records for 42,000 patients.

Main Results:

PGx-CDS was implemented covering 45 drug-gene interactions.
Data from 42,000 patients with PGx test results were incorporated.
Approximately 9,281 CDS interventions were triggered at the time of prescribing in 2023.

Conclusions:

The multidisciplinary PGx-CDS program has been successfully implemented.
The high number of triggered interventions indicates significant impact on prescribing practices.
The program demonstrates the feasibility and success of integrating PGx into routine clinical care.