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Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

Particle Shape Modulates the Function of Adoptive Macrophage Transfers.

Matthew M C Kwan¹, Nicole B Day², Iain R Konigsberg³

¹Materials Science and Engineering Program, University of Colorado Boulder, Boulder, CO, 80303, USA.

Advanced Healthcare Materials

|August 8, 2025

Summary

Particle shape influences macrophage behavior for adoptive cell transfers (ACTs). Spherical particles promote pro-inflammatory responses, while discoidal particles offer functional flexibility, enhancing tumor targeting without compromising delivery.

Keywords:

adoptive cell transfer cancer drug delivery macrophage microparticle nanoparticle

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Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

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Published on: June 7, 2017

Area of Science:

Biomedical Engineering
Immunology
Materials Science

Background:

Adoptive cell transfers (ACTs) are emerging for nanoparticle delivery.
Macrophages (Mφ) are promising carriers due to their targeting and phagocytic capabilities.
Understanding how particle shape affects Mφ function in ACTs is crucial.

Purpose of the Study:

To investigate macrophage interactions with spherical and discoidal particles.
To evaluate the impact of particle shape on Mφ function and tumor delivery.
To determine if particle shape can be a design parameter for ACTs.

Main Methods:

Macrophage interaction studies with biodegradable spherical and discoidal particles.
In vivo adoptive transfer of Mφ-S and Mφ-D to B16-F10 tumor models.
Analysis of Mφ phenotype, transcriptional, chromatin accessibility, and protein state.

Main Results:

Mφ-S and Mφ-D exhibited enhanced tumor targeting compared to free microparticles.
Mφ-S showed epigenetic changes and biomarkers associated with a pro-inflammatory phenotype.
Mφ-D displayed a mixed pro- and anti-inflammatory profile, indicating functional flexibility.

Conclusions:

Particle shape significantly influences macrophage phenotype and function in ACTs.
Biodegradable particle shape can be engineered to modulate Mφ behavior for improved therapeutic delivery.
This study provides a design strategy for optimizing ACTs using particle shape.