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Serum Vitamin B12 Level in Children with Type 1 Diabetes

Santosh Pradhan1, Subhana Thapa2, Pradeep Krishna Shrestha3

  • 1Department of Biochemistry, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Journal of Nepal Health Research Council
|August 8, 2025
PubMed

Insights

Type 1 diabetes patients often have low vitamin B12 levels, with many showing deficiency or subclinical deficiency. Routine screening for vitamin B12 is recommended for individuals with Type 1 diabetes.

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Metabolic Disorders

Background:

  • Type 1 Diabetes Mellitus (T1DM) is linked to various comorbidities.
  • Vitamin B12 deficiency is a potential, often overlooked, comorbidity in T1DM patients.

Purpose of the Study:

  • To evaluate serum vitamin B12 levels in a cohort of T1DM patients.
  • To compare vitamin B12 levels between T1DM patients and healthy non-diabetic individuals.

Main Methods:

  • A cross-sectional study involving 40 T1DM patients and 30 healthy controls.
  • Assessment of serum vitamin B12, C-peptide, creatinine, blood glucose, and glycosylated hemoglobin.
  • Data analysis using SPSS version 22.

Main Results:

  • Mean serum vitamin B12 was significantly lower in T1DM patients (206.92±82.18 pmol/L) compared to controls (340.71±136.02 pmol/L).
  • Vitamin B12 deficiency was observed in 40% of T1DM patients, with an additional 37.5% showing subclinical deficiency.
  • Only 6.7% of controls were deficient, and 26.75% were subclinically deficient.

Conclusions:

  • This study highlights the prevalence of low serum vitamin B12 in Type 1 diabetics.
  • Routine screening, confirmatory testing, and clinical examination for vitamin B12 deficiency are beneficial for T1DM patients.
Abstract

Keywords:
Autoimmune disease; Type 1 Diabetes mellitus; Vitamin B12.

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