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Approach to Cardiovascular Autonomic Dysfunction in Patients with Synucleinopathies
1Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Movement Disorders Clinical Practice
|August 8, 2025
Summary
Orthostatic hypotension and supine hypertension are common in synucleinopathies like Parkinson's disease. This review details their pathophysiology, diagnosis, and management for better patient outcomes.
Area of Science:
- Neurology
- Autonomic Neuroscience
Background:
- Autonomic dysfunction, including orthostatic hypotension (OH) and supine hypertension (SH), is prevalent in synucleinopathies (Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, pure autonomic failure).
- OH and SH contribute to adverse outcomes like cognitive decline and motor symptom exacerbation.
- Atypical OH presentations often overlap with synucleinopathy symptoms, necessitating increased clinical awareness.
Purpose of the Study:
- To provide a focused review on managing cardiovascular autonomic dysfunction in synucleinopathies.
- To inform clinical decision-making and guide future research in this area.
Main Methods:
- This study is a narrative review.
- It comprehensively discusses the approach to OH and SH in synucleinopathies.
Main Results:
- The review covers the pathophysiology of OH and SH in synucleinopathies.
- It details diagnostic criteria for OH and SH.
- Management strategies, including non-pharmacological, pharmacological, and experimental approaches, are discussed.
Conclusions:
- Effective management of OH and SH is crucial for improving quality of life in synucleinopathy patients.
- Further research into novel therapeutic strategies is warranted.
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