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Assessing Activity-based Anorexia in Mice
Published on: May 14, 2018
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Diminished Motivation for Voluntary Exercise and Metabolic Dysfunction in Psychiatric Disorders: A Behavioral
Dong-Joo Hwang1,2, Kyeong-Ri Kim1, Tae-Kyung Kim1,2
1Exercise Biochemistry Laboratory, Korea National Sport University, Seoul, Korea.
International Neurourology Journal
|August 8, 2025
Summary
Animal models of autism spectrum disorder (ASD) and major depressive disorder (MDD) show reduced motivation for exercise. These findings link behavioral and metabolic changes, suggesting interventions to boost motivation and energy balance are crucial.
Area of Science:
- Neuroscience
- Metabolic Research
- Psychiatry
Background:
- Autism Spectrum Disorder (ASD) and Major Depressive Disorder (MDD) are complex psychiatric conditions.
- Understanding the interplay between behavior and metabolism is crucial for developing effective treatments.
Purpose of the Study:
- Investigate spontaneous locomotor activity and metabolic phenotype in animal models of ASD and MDD.
- Focus on the motivation to engage in voluntary exercise in these models.
Main Methods:
- Utilized Shank3B-knockout mice as an ASD model and stress-susceptible mice under chronic restraint stress (CRSTSUS) as an MDD model.
- Assessed spontaneous locomotion, voluntary wheel running, and metabolic phenotypes using indirect calorimetry and behavioral tests.
Main Results:
- Shank3B-knockout mice displayed self-injurious behaviors, while CRSTSUS mice exhibited behavioral despair, reduced locomotion, and decreased exercise motivation.
- Significant metabolic dysregulation was observed, including altered oxygen consumption, carbon dioxide production, respiratory exchange ratio, and energy expenditure.
Conclusions:
- Behavioral and metabolic alterations are interconnected in psychiatric disorders.
- Reduced motivation for exercise is a key phenotypic signature in these conditions.
- Targeted interventions are needed to restore intrinsic motivation and energy balance for enhanced physical activity engagement.
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