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Updated: Sep 12, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Electroreductive Cross-Electrophile Coupling of Aromatic Ketones and N,N-Dimethylformamide Enabling the Synthesis of
Jing Lei1, Fen Han1, Sheng Li1
1Precise Synthesis and Function Development Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China.
Abstract:
α-Hydroxyaldehydes are powerful multifunctional structural motifs for the production of clinical drugs and value-added compounds. The known methods typically suffer from limitations such as the requirement for strong bases, toxic reagents, and the necessity of multistep reactions. Here, we developed a straightforward synthetic method of α-hydroxyaldehydes via an electroreductive umpolung formylation of aromatic ketones utilizing readily available N,N-dimethylformamide as formylation reagents. This approach will provide an efficient strategy for the acquisition of α-hydroxyaldehydes.
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