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Cardiovascular Aging.

Marco Tana1,2, Rachele Piccinini3, Livia Moffa4

  • 1Internal Medicine and Cardiovascular Ultrasound Unit, Medical Department, SS. Annunziata Hospital, 66100 Chieti, Italy.

Reviews in Cardiovascular Medicine
|August 8, 2025
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Summary
This summary is machine-generated.

Aging accelerates cardiovascular disease through oxidative stress and inflammaging, leading to heart dysfunction. This review explores mechanisms and therapies to mitigate these aging-related cardiovascular changes for improved health.

Keywords:
cardiac amyloidosiscardiovascular agingejection fractionheart failureoxidative stress

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Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Molecular Biology

Background:

  • Aging progressively impacts cardiovascular system function, leading to diastolic/systolic dysfunction, vascular stiffening, and endothelial impairment.
  • Key age-related cardiovascular changes include extracellular matrix (ECM) excess, reduced matrix metalloproteinases (MMPs), and amyloid/calcium deposits.
  • Aging is linked to oxidative stress, mitochondrial dysfunction, and 'inflammaging'—a chronic, low-grade inflammatory state.

Purpose of the Study:

  • To describe the mechanisms underlying age-related cardiovascular alterations.
  • To explore novel therapeutic strategies targeting oxidative stress and inflammaging in cardiovascular aging.
  • To highlight the role of biomarkers and imaging in stratifying treatment for cardiovascular aging.

Main Methods:

  • Review of current literature on aging mechanisms and cardiovascular disease.
  • Analysis of molecular and cellular pathways involved in cardiovascular aging.
  • Exploration of emerging therapeutic interventions and diagnostic approaches.

Main Results:

  • Aging significantly increases cardiovascular disease risk, mortality, and morbidity.
  • Oxidative stress and inflammaging are central to age-related cardiovascular pathology.
  • Therapeutic strategies targeting these pathways show promise in mitigating cardiovascular aging.

Conclusions:

  • Understanding the mechanisms of cardiovascular aging is crucial for developing effective interventions.
  • Targeting oxidative stress and inflammaging offers potential for delaying cardiovascular aging and improving longevity.
  • Integrated approaches using biomarkers and imaging can optimize treatment strategies for older adults with cardiovascular conditions.