Vitamin D as a Key Mediator Between C-reactive Protein to Albumin Ratio and Congestive Heart Failure in an Elderly Population: An Innovative Exploration Using the NHANES Database
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View abstract on PubMed
Summary
This summary is machine-generated.The C-reactive protein-to-albumin ratio (CAR) and vitamin D deficiency are linked to higher congestive heart failure (CHF) risk in older adults. Vitamin D partially mediates this relationship, highlighting its role in cardiovascular disease prevention.
Area Of Science
- Gerontology and Cardiovascular Medicine
- Biomarkers and Disease Risk Assessment
Background
- The C-reactive protein-to-albumin ratio (CAR), a marker of inflammation and nutritional status, is linked to increased mortality in congestive heart failure (CHF).
- The potential role of vitamin D in modulating the relationship between CAR and CHF remains unclear.
- Understanding this interaction is crucial for cardiovascular disease prevention strategies in older adults.
Purpose Of The Study
- To investigate the mediating role of vitamin D in the association between CAR and CHF in older adults.
- To analyze the independent associations of CAR and 25-hydroxyvitamin D [25(OH)D] with CHF.
- To explore implications for cardiovascular disease prevention strategies.
Main Methods
- Analysis of data from the National Health and Nutrition Examination Survey (NHANES) 2001-2010 for adults aged ≥65 years.
- Multivariate logistic regression to assess independent associations of CAR and 25(OH)D with CHF.
- Mediation analysis (Hayes' PROCESS Model 4) to test the mediating effect of 25(OH)D on the CAR-CHF link.
Main Results
- Elevated CAR was an independent risk factor for CHF (adjusted OR: 1.96).
- Vitamin D deficiency (<20 ng/mL) was associated with a significantly higher risk of CHF compared to sufficiency (≥30 ng/mL) (OR: 0.56).
- 25-hydroxyvitamin D partially mediated the CAR-CHF association, explaining 3.00% of the total effect (indirect effect: 0.002).
Conclusions
- Elevated CAR and vitamin D deficiency are independently associated with increased CHF risk in older adults.
- Vitamin D plays a partial mediating role in the CAR-CHF association, linking inflammation/nutrition to cardiovascular risk.
- Monitoring CAR and vitamin D levels is recommended for CHF prevention, with a focus on inflammation control and vitamin D repletion.
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