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Case Report: The huge esophageal displacement: a case of dramatic esophageal interfraction motion during neoadjuvant

Renba Liang¹, Jing Jin¹, Jianghu Zhang¹

¹Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

Frontiers in Immunology

|August 8, 2025

Abstract

Background:

The average movement of esophagus is about 0.15 to 0.4 cm radially and 0.3 to 0.9 cm in the superior-inferior during radiotherapy. Little study has reported giant shift of esophagus during neoadjuvant chemotherapy and immunotherapy.

Case Presentation:

Here we presented a case of a 72-year-old male patient diagnosed with advanced lower thoracic esophageal squamous cell cancer, clinical T2N2M1, stage IVB (pulmonary metastasis). The esophagus moved about 4.2 cm radially from the right to the left of the aorta after 2 cycles of chemotherapy and immunotherapy.

Conclusion:

All in all, we treated a patient with advanced lower thoracic esophageal squamous cell cancer that occurred a dramatic radial escape of about 4.2 cm after 2 cycles of chemotherapy and immunotherapy.

Keywords:

chemotherapy esophageal cancer immunotherapy motion radiotherapy

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