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Multifunctional gold nanoclusters as next-generation theranostic platforms for disease management
Yan Sun1,2, Yining Chen1, Xiaoyang Hu1
1Key Laboratory of Advanced Biomaterials and Nanomedicine in Universities of Shandong, Linyi University, Linyi 276000, China.
International Journal of Pharmaceutics: X
|August 8, 2025
Summary
Gold nanoclusters (GNCs) offer tunable properties and biocompatibility for advanced nanomedicine. This review explores their synthesis and cutting-edge applications in disease theranostics, guiding future personalized medicine innovations.
Area of Science:
- Nanotechnology
- Materials Science
- Biomedical Engineering
Background:
- Gold nanoclusters (GNCs) are nanomaterials (<3 nm) with unique molecule-like properties.
- GNCs exhibit high photostability and excellent biocompatibility.
- These characteristics position GNCs as promising platforms for nanomedicine.
Purpose of the Study:
- To review synthesis methodologies for gold nanoclusters.
- To highlight cutting-edge applications of GNCs in disease management.
- To discuss challenges and opportunities for GNCs in theranostics.
Main Methods:
- Literature review of GNC synthesis.
- Analysis of recent GNC applications in bioimaging and sensing.
- Examination of GNCs in drug delivery and cancer therapy.
Main Results:
- GNCs demonstrate versatility in bioimaging, sensing, and drug delivery.
- Applications span various diseases, including cancer.
- GNCs show potential as effective theranostic agents.
Conclusions:
- GNCs are powerful tools for precise nanomedicine and personalized healthcare.
- Further research can optimize GNC-based theranostic platforms.
- Interdisciplinary innovation is key to advancing GNC applications.
