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Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
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Urinary microbiome and urological cancers: a mini review
Gianmarco Randazzo1, Eleonora Bovolenta1, Tommaso Ceccato1
1Department of Surgery, Oncology and Gastroenterology, Urologic Unit, University of Padova, Padua, Italy.
Frontiers in Urology
|August 8, 2025
Summary
The urinary microbiome (UMB) is linked to urologic cancers. Alterations in UMB composition may influence cancer development and treatment response, offering potential for new therapies.
Area of Science:
- Urology
- Microbiology
- Oncology
Background:
- The urinary microbiome (UMB) comprises bacteria, their genomes, and products, interacting with the host.
- Changes in UMB composition are associated with benign urological disorders and urologic cancers.
- UMB may influence cancer development through local inflammation and immune system interactions.
Purpose of the Study:
- To investigate the association between the urinary microbiome and the development of urologic cancers.
- To explore the role of UMB in cancer progression and treatment response.
Main Methods:
- A non-systematic literature review of studies published within the last 5 years.
- Database search using PubMed for human patient studies involving the UMB.
- Narrative analysis of identified literature to explore UMB-urologic cancer associations.
Main Results:
- In bladder cancer (BC), UMB may affect metastasis and BCG treatment response. Bacterial richness differs between cancer and non-neoplastic groups and between NMIBC and MIBC.
- Prostate cancer (PCa) shows an abundance of pro-inflammatory bacteria and uropathogens.
- Limited data exists for renal cell carcinoma (RCC), penile, and testicular cancers regarding UMB associations.
Conclusions:
- Understanding the UMB's role in urologic tumors can lead to novel therapeutic strategies.
- Insights into UMB could improve patient risk stratification for urologic cancers.
Keywords:
BCG (Bacille Calmette-Guérin)UTUC (renal pelvis and ureter)bladder cancermicrobiome and dysbiosisprostate cancerrenal cell carcinomaurinary microbiomeMore Related Videos
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