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Related Experiment Video

Updated: Sep 12, 2025

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases
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Cryo-Depleted Plasma Infusions for Ligneous Conjunctivitis.

Anna Bonde Scheel-Bech1, Marie Louise Roed Rasmussen1, Steffen Heegaard1,2

  • 1Department of Ophthalmology, University Hospital, Rigshospitalet, Copenhagen, Denmark.

Case Reports in Ophthalmology
|August 8, 2025
PubMed
Summary
This summary is machine-generated.

Ligneous conjunctivitis, a rare condition, was successfully treated in a pediatric patient with plasminogen (PLG) deficiency using cryo-depleted plasma infusions and cyclosporine. This combined therapy offers a promising long-term treatment for PLG-deficiency-related ligneous conjunctivitis.

Keywords:
Cryo-depleted plasmaLigneous conjunctivitisPediatricsPlasminogen deficiencyTopical cyclosporine

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Area of Science:

  • Ophthalmology
  • Genetics
  • Hematology

Background:

  • Ligneous conjunctivitis is a rare, chronic inflammatory condition characterized by pseudomembrane formation on the conjunctiva.
  • Plasminogen (PLG) deficiency is an underlying genetic cause, often associated with systemic comorbidities.
  • This report details a case of pediatric ligneous conjunctivitis secondary to PLG deficiency.

Observation:

  • A 12-year-old girl presented with chronic ocular symptoms including itching, irritation, and photophobia.
  • Clinical examination revealed pseudomembranes and giant papillae; histological analysis confirmed fibrin and inflammatory cells.
  • The patient had a history of severe congenital comorbidities and parental consanguinity, prompting genetic investigation.

Findings:

  • Genetic analysis identified homozygosity for a pathogenic variant in the PLG gene, confirming PLG deficiency.
  • The patient's ligneous conjunctivitis was successfully managed with a regimen of cryo-depleted plasma infusions and topical cyclosporine.
  • Complete remission of conjunctival pseudomembranes was achieved with this therapeutic approach.

Implications:

  • This case underscores the significance of considering PLG deficiency in recurrent chronic conjunctivitis, especially in the presence of systemic issues.
  • Long-term cryo-depleted plasma infusions combined with topical cyclosporine present a viable and effective treatment strategy for ligneous conjunctivitis in PLG-deficient individuals.
  • Early diagnosis and targeted therapy can significantly improve outcomes for patients with this rare condition.