A Case of Sickle Cell Beta Thalassemia and Recurrent Septicemia

Sickle cell anemia and beta-thalassemia are among the most common hemoglobin disorders. They are characterized by abnormal hemoglobin production, leading to ineffective erythropoiesis and severe anemia. Compound forms, such as sickle cell beta-thalassemia (HbS/β-thalassemia), may experience a wide range of complications, including impaired splenic function and increased susceptibility to infections. In this case report, we describe the case of a 57-year-old female patient with sickle cell/beta0-thalassemia (Sß0) with frequent and prolonged hospital admissions for sepsis complicated by recurrent liver abscess requiring multiple procedures for intrahepatic drainage. This patient was found to have an abscess with cholelithiasis, with a multiseptated hypodense collection within the liver. Recurrent liver abscesses are rare and underreported in this population. This case highlights the need for further research to clarify pathophysiology and ultimately improve management.