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Are TP53 Arg72Pro and MDM2 T309G polymorphisms associated with bladder cancer risk? A meta-analysis
Rym-Khadidja Abderrahmane1,2, Zohra Touala-Chaila1,2, Khedidja Benseddik2,3
1Université des Sciences et de la Technologie d'Oran Mohamed-Boudiaf USTOMB El Mnaouar, BP 1505, Bir El Djir 31000, Oran, Algérie.
African Health Sciences
|August 8, 2025
Summary
The MDM2 T309G polymorphism may increase bladder cancer risk in the Turkish population. Further research is needed to confirm the association between TP53 Arg72Pro and bladder cancer risk.
Area of Science:
- Genetics and Epidemiology
- Cancer Research
Background:
- The exact cause of bladder cancer (BC) remains unknown.
- Genetic factors may play a role in BC development.
Purpose of the Study:
- To evaluate the association between TP53 Arg72Pro and MDM2 T309G polymorphisms and the risk of bladder cancer.
- To synthesize existing evidence through a meta-analysis.
Main Methods:
- A comprehensive literature search was performed.
- A meta-analysis of 14 relevant studies was conducted.
- Sensitivity and subgroup analyses were utilized to explore heterogeneity.
Main Results:
- Overall, no statistically significant association was found between the studied polymorphisms and bladder cancer risk.
- However, subgroup analysis revealed a significant association for the MDM2 T309G polymorphism in the Turkish population.
- Sensitivity analysis indicated significant associations for both TP53 Arg72Pro and MDM2 T309G with BC occurrence under specific models.
Conclusions:
- The MDM2 T309G polymorphism may act as a predisposing genetic factor for bladder cancer in the Turkish population.
- The role of TP53 Arg72Pro in bladder cancer requires further investigation.
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