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Related Experiment Video

Updated: Sep 12, 2025

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
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Biomimetic Nanoparticles with Sustained-Release for Stepwise Targeting Ion Channels in Inhibiting Leukemia Cell

Boying Li1, Ran Zhang2, Nana Wang2

  • 1Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300401, P.R. China.

ACS Applied Bio Materials
|August 8, 2025
PubMed
Summary

New biomimetic nanoparticles effectively target acute myeloid leukemia (AML) cells. These nanoparticles inhibit AML growth by regulating intracellular signals, offering a novel therapeutic strategy for this challenging cancer.

Keywords:
biomimeticdrug resistanceion channelsstepwise targetingsustained release

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Biology

Background:

  • Acute myeloid leukemia (AML) presents significant therapeutic challenges due to rapid progression, high aggressiveness, and drug resistance.
  • Effective targeting strategies are crucial for improving AML treatment outcomes.

Purpose of the Study:

  • To design and prepare biomimetic sustained-release nanoparticles (PLGA-C-M) for inhibiting AML survival and resistance pathways.
  • To investigate the mechanism of PLGA-C-M in targeting AML cells and regulating intracellular signaling.

Main Methods:

  • Development of biomimetic nanoparticles (PLGA-C-M) using leukemia cell membranes for targeted delivery.
  • Administration of nanoparticles for sustained drug release and targeting of TRPM2 ion channels highly expressed in AML.
  • Evaluation of nanoparticle effects on AML cell growth, mitochondrial function, autophagy, and drug resistance.

Main Results:

  • PLGA-C-M nanoparticles successfully targeted AML cells and achieved sustained drug release.
  • Targeting of TRPM2 ion channels led to progressive modulation of intracellular Ca2+ signaling.
  • Inhibition of AML cell growth was observed through destruction of mitochondrial function, reduction of autophagy, and overcoming drug resistance.

Conclusions:

  • Biomimetic nanoparticles offer a promising approach for AML therapy by simultaneously regulating intracellular ROS and Ca2+ signals.
  • This strategy provides novel insights into the regulation of ion channel-related signal transduction in AML treatment.