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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Anticoronavirus Activity of Uridine Glycoconjugates Containing a 1,2,3-Triazole Moiety

Malgorzata Graul1,2, Gabriela Brzuska1, Ewa Wisniewska1

  • 1Laboratory of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, Gdansk 80-307, Poland.

Journal of Medicinal Chemistry
|August 8, 2025
PubMed

Insights

New uridine glycoconjugates show broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2. These novel compounds offer potential as effective treatments for widespread coronavirus infections.

Area of Science:

  • Virology
  • Medicinal Chemistry
  • Drug Discovery

Background:

  • Coronaviruses cause severe respiratory and enteric diseases in vertebrates.
  • Seven human coronaviruses are known, including SARS-CoV-2, necessitating new antiviral therapies despite vaccine availability.

Purpose of the Study:

  • To synthesize and evaluate uridine glycoconjugates as potential broad-spectrum antiviral agents.
  • To investigate the efficacy of these compounds against model coronaviruses and SARS-CoV-2.

Main Methods:

  • Synthesis of uridine glycoconjugates incorporating a 1,2,3-triazole moiety.
  • Antiviral testing against murine hepatitis virus (MHV) and human coronavirus NL63 (HCoV-NL63).
  • Confirmation of efficacy against SARS-CoV-2.

Main Results:

  • Four synthesized compounds exhibited significant antiviral activity against MHV and HCoV-NL63.
  • These compounds demonstrated confirmed efficacy against SARS-CoV-2.
  • The compounds appear to inhibit coronavirus infectivity and replication.

Conclusions:

  • Novel uridine glycoconjugates show promise as broad-spectrum antiviral inhibitors.
  • These compounds represent a potential new avenue for treating coronavirus infections.

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