Predicting Visual Acuity in Pseudophakic Eyes With Pupil-Dependent Extended Depth of Focus Intraocular Lenses

To analyze the impact of the pupil size on the prediction of the clinical monocular visual acuity (VA) with a representative pupil-dependent extended depth of focus intraocular lens (EDOF IOL).

An optical bench with a model eye was used to obtain with 2-, 3-, and 4.5-mm pupils (at the IOL plane) the through-focus area under the modulation transfer function (TF-MTFa) of the refractive EDOF AcrySof IQ Vivity (Alcon Laboratories, Inc). The TF-MTFa curve with a 3-mm pupil was correlated with the clinical VA defocus curve (R² = 0.95) of a large sample of pseudophakic patients (n = 107). This group also was split into three cohorts according to pupil size: small (< 3 mm; n = 6), medium (3 to 4 mm; n = 52), and large (> 4 mm; n = 49). Each pupil group showed a differentiated clinical VA defocus curve that was highly correlated with the 2- (R² = 0.97), 3- (R² = 0.97), and 4.5-mm (R² = 0.96) TF-MTFa, respectively. The clinical VA versus MTFa curves were fitted using the formula proposed by the American National Standards Institute to derive for each pupil a new set of fitting coefficients to transform MTFa into expected VA accordingly.

Four new predictive functions of the clinical VA were obtained for the pupil-dependent refractive EDOF IOL: one for the whole sample of patients, which averages out pupillary differences between patients, and three functions that incorporate the influence of the pupil size.

Better prediction of the clinical VA of pseudophakic patients implanted with pupil-dependent refractive EDOF IOLs is achieved with fitting functions that take into account the pupil size.