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Updated: Sep 12, 2025

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Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
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SeCoV2: Semantic Connectivity-Driven Pseudo-Labeling for Robust Cross-Domain Semantic Segmentation
Summary
SeCo and SeCoV2 improve cross-domain semantic segmentation by refining pseudo-labels using semantic connectivity. This approach enhances model robustness and performance, especially under significant domain shifts.
Area of Science:
- Computer Vision
- Machine Learning
- Artificial Intelligence
Background:
- Pseudo-labeling is key for cross-domain semantic segmentation (CDSS) but struggles with noisy predictions under domain shifts.
- Existing methods often produce fragmented and inaccurate pixel-level labels, limiting performance.
Purpose of the Study:
- To introduce a novel pseudo-labeling framework, SeCo, that leverages semantic connectivity for improved CDSS.
- To present SeCoV2, an enhanced version addressing ambiguity and expanding applicability to challenging scenarios.
Main Methods:
- SeCo aggregates high-confidence pixels into semantic regions using Pixel Semantic Aggregation (PSA) and Semantic Connectivity Correction with Loss Distribution (SCC-LD).
- SeCoV2 incorporates SCC-Unc for uncertainty-aware refinement, building a connectivity graph for relational consistency.
- Compatibility with interactive foundation models (SAM, SEEM, Fast-SAM) was validated.
Main Results:
- SeCoV2 achieved consistent improvements across six CDSS tasks, with an average performance gain of up to +4.6%.
- New state-of-the-art results were established in various CDSS benchmarks.
- The framework demonstrated robust adaptation capabilities in diverse, real-world environments.
Conclusions:
- The semantic connectivity-driven approach significantly enhances pseudo-label quality and segmentation accuracy.
- SeCoV2 offers superior generalization and robustness, outperforming previous methods in challenging CDSS scenarios.
- The proposed methods provide a powerful tool for effective domain adaptation in semantic segmentation.
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