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Updated: Sep 12, 2025

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
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SeCoV2: Semantic Connectivity-Driven Pseudo-Labeling for Robust Cross-Domain Semantic Segmentation.

Dong Zhao, Qi Zang, Nan Pu

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    Summary
    This summary is machine-generated.

    SeCo and SeCoV2 improve cross-domain semantic segmentation by refining pseudo-labels using semantic connectivity. This approach enhances model robustness and performance, especially under significant domain shifts.

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    Area of Science:

    • Computer Vision
    • Machine Learning
    • Artificial Intelligence

    Background:

    • Pseudo-labeling is key for cross-domain semantic segmentation (CDSS) but struggles with noisy predictions under domain shifts.
    • Existing methods often produce fragmented and inaccurate pixel-level labels, limiting performance.

    Purpose of the Study:

    • To introduce a novel pseudo-labeling framework, SeCo, that leverages semantic connectivity for improved CDSS.
    • To present SeCoV2, an enhanced version addressing ambiguity and expanding applicability to challenging scenarios.

    Main Methods:

    • SeCo aggregates high-confidence pixels into semantic regions using Pixel Semantic Aggregation (PSA) and Semantic Connectivity Correction with Loss Distribution (SCC-LD).
    • SeCoV2 incorporates SCC-Unc for uncertainty-aware refinement, building a connectivity graph for relational consistency.
    • Compatibility with interactive foundation models (SAM, SEEM, Fast-SAM) was validated.

    Main Results:

    • SeCoV2 achieved consistent improvements across six CDSS tasks, with an average performance gain of up to +4.6%.
    • New state-of-the-art results were established in various CDSS benchmarks.
    • The framework demonstrated robust adaptation capabilities in diverse, real-world environments.

    Conclusions:

    • The semantic connectivity-driven approach significantly enhances pseudo-label quality and segmentation accuracy.
    • SeCoV2 offers superior generalization and robustness, outperforming previous methods in challenging CDSS scenarios.
    • The proposed methods provide a powerful tool for effective domain adaptation in semantic segmentation.