Related Experiment Video
Updated: Sep 12, 2025

Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Platelet and Coagulation Abnormalities in Pediatric Hematological Malignancies: Potential for Hemorrhagic Events
Background:
The purpose of the study was to evaluate the platelet counts and coagulation profiles in pediatric patients with the most common types of hematological malignancies (HMs) to assess the predisposition to thrombotic and hemorrhagic complications.
Methods:
This is a retrospective study carried out from 2016 to 2022. The research encompassed 172 children under the age of 16 diagnosed with HMs. The data were obtained from King Salman Medical City's Maternity and Children's Hospital in Madinah, Saudi Arabia.
Results:
Platelet count was statistically observed to be low in all prevalent types of HMs in our study, including B-cell acute lymphoblastic leukemia (B-ALL), acute myelomonocytic leukemia (AML-M4), T-cell acute lymphoblastic leukemia (T-ALL), and acute promyelocytic leukemia (AML-M3). The coagulation profile exhibited variability, with prothrombin time (PT), activated partial thromboplastin time (APTT), and international normalized ratio (INR) significantly prolonged in AML-M3 patients, while only PT and INR were prolonged in other types.
Conclusions:
The study data reveals significant alterations in platelet count and coagulation profiles in pediatric patients with HMs, indicating an increased risk of hemorrhagic complications. The subtype of HMs may specifically influence clinical complications associated with thrombotic and hemorrhagic events and should be consid-ered in the evaluation of platelets and coagulation profiles.
More Related Videos
04:37Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
Published on: May 23, 2025
09:38A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
Published on: February 14, 2017
Related Concept Videos
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Venous Thrombosis IV: Nursing Management
Structure and Function of Platelets
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...