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hsa_circ_0002872 functions in lung cancer prognostic and tumorigenesis through regulating ZBTB46 via sponging hsa-miR-29b-1-5p

  • 0Department of Oncology, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing 210003, Jiangsu, China.
Clinics +

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August 8, 2025

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August 8, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study identified a novel circular RNA (circRNA) pathway involving ZBTB46 that may inhibit lung cancer progression. This pathway could serve as a new biomarker for lung cancer prognosis and treatment.

Area Of Science

  • Oncology
  • Molecular Biology
  • Biomarker Discovery

Background

  • Lung cancer remains a major global health challenge, necessitating novel diagnostic and prognostic biomarkers.
  • Circular RNAs (circRNAs) are emerging as promising candidates for cancer detection.
  • The ZBTB46 gene has been implicated in lung cancer prognosis.

Purpose Of The Study

  • To investigate circRNA expression profiles in lung cancer.
  • To explore the role of ZBTB46 in lung cancer development and progression.
  • To identify potential circRNA-based biomarkers for lung cancer.

Main Methods

  • High-throughput sequencing (RNA-seq) to identify differentially expressed circRNAs (DEcircRNAs).
  • Bioinformatic analyses including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.
  • Validation using quantitative real-time PCR (qRT-PCR) and analysis of public databases (TCGA, CPTAC, HPA) for ZBTB46 expression.

Main Results

  • Identified 411 DEcircRNAs, with 365 down-regulated and 46 up-regulated in lung cancer tissues.
  • Predicted the hsa_circ_0002872/hsa-miR-29b-1-5p/ZBTB46 axis as a key regulatory pathway.
  • Observed reduced ZBTB46 mRNA and protein expression in lung cancer tissues compared to normal tissues.

Conclusions

  • The hsa_circ_0002872/hsa-miR-29b-1-5p/ZBTB46 axis plays a role in lung cancer progression.
  • ZBTB46 may function as a tumor suppressor, inhibiting lung cancer progression.
  • ZBTB46 holds potential as a valuable prognostic biomarker for lung cancer.

Keywords:

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