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Updated: Aug 1, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
Published on: January 14, 2014
Plot twist: TET2 clones save the brain
Maria A Telpoukhovskaia1, Jennifer J Trowbridge1
1The Jackson Laboratory, Bar Harbor, ME, USA.
Abstract:
While clonal hematopoiesis (CH) is associated with protection from Alzheimer's disease (AD), a limited understanding of the mechanisms by which this occurs has been a barrier to therapeutic intervention. In a new study, Matatall et al.1 discover protective mechanisms by which TET2-mutant, but not DNMT3A-mutant, CH impacts dementia pathology and cognition.
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