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Updated: Jul 23, 2026

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation
Published on: April 13, 2011
Revolutionizing islet transplantation with a preconditioning boost for beta cell survival
Kewen Hu1, Yajie Chen2, Zhen Zhang2
1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Clinical Research Center for Radiation Oncology, Shanghai 200032, China; Shanghai Key Laboratory of Radiation Oncology, Shanghai 200032, China; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Abstract:
The poor survival of islets post-transplantation remains a significant challenge for type 1 diabetes mellitus (T1DM) therapy. Vandana et al.1 develop ChemPerturb-seq, which is integrated with in vivo barcoded screening to identify small molecule cocktails that enhance human beta cell and islet survival after transplantation, offering promising strategies for T1DM.
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