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Stroke and cervical artery dissection and/or aneurysm: 2019-2021 Chilean hospital-based national registry

Ma Ignacia Allende1, Paula Muñoz Venturelli2, Enrico Mazzon3

  • 1Centro de Estudios Clínicos, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile; The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|August 8, 2025
PubMed

Insights

Stroke risk in cervical artery dissection (CeDA) patients in Chile is higher in men and those with vertebral artery involvement, hypertension, smoking, or atrial fibrillation. These findings highlight key risk factors for stroke in this population.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Epidemiology

Background:

  • Cervical artery dissection (CeDA) is a leading cause of stroke in young adults.
  • Existing data on CeDA patient characteristics are predominantly from Caucasian populations.
  • This study focuses on identifying stroke-associated characteristics in Chilean CeDA patients.

Purpose of the Study:

  • To identify patient characteristics associated with stroke in individuals with cervical artery dissection or aneurysm (CeDA) in Chile.
  • To analyze risk factors specific to a South American population.
  • To examine the impact of the COVID-19 pandemic on CeDA admissions.

Main Methods:

  • Retrospective analysis of a national hospital-based database in Chile (2019-2021).
  • Identification of CeDA patients using ICD-10 codes I72.0 and I72.6.
  • Multivariable logistic regression to assess stroke risk factors and Poisson regression for pandemic impact.

Main Results:

  • Among 597 CeDA patients, 37% experienced a stroke, predominantly ischemic (71%).
  • Stroke occurrence was significantly associated with vertebral artery involvement (OR 2.89), atrial fibrillation (OR 2.25), hypertension (OR 1.85), male sex (OR 1.80), and current smoking (OR 1.78).
  • CeDA hospital admissions decreased in 2020 and 2021 compared to 2019.

Conclusions:

  • In Chile, male sex, vertebral artery involvement, hypertension, current smoking, and atrial fibrillation are linked to stroke in CeDA patients.
  • These findings underscore the importance of these risk factors in a non-Caucasian cohort.
  • Further investigation is warranted to elucidate underlying mechanisms and prognostic implications.
Abstract

Keywords:
Carotid artery dissectionCervical artery aneurismCervical artery dissectionRisk factorsStrokeVertebral artery dissection

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