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Related Experiment Video

Updated: Sep 12, 2025

Multimodality Diagnosis of Mesenteric Ischemia

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Published on: July 21, 2023

Multimodal Diagnostic Approach in Cardiac Myeloid Sarcomas.

Luis A Ortiz¹, Onyee Chan²

¹Department of Medicine, Internal Medicine Residency, University of South Florida, Tampa, Florida, USA.

JACC. Case Reports

|August 8, 2025

Summary

Cardiac myeloid sarcomas (CMS) are rare but can occur in patients with hematologic malignancies. A multimodal diagnostic approach is crucial for timely diagnosis and management in at-risk populations.

Keywords:

bradycardia cancer cardiac magnetic resonance chest pain echocardiography shortness of breath

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Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

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Published on: April 15, 2022

Area of Science:

Hematology
Cardiology
Oncology

Background:

Myeloid sarcomas are uncommon extramedullary infiltrations of immature myeloid cells.
These infiltrations are associated with leukemic, myeloproliferative, and myelodysplastic syndromes.
Cardiac involvement can lead to diverse clinical manifestations depending on the affected cardiac structures.

Observation:

A 61-year-old male with a history of acute myeloid leukemia, post-hematopoietic stem cell transplant, and prior myeloid sarcomas of the kidney and eye presented with chest pain.
Electrocardiogram revealed new atrioventricular nodal disease.
The patient was diagnosed with new cardiac myeloid sarcomas (CMS).

Findings:

Endomyocardial biopsy is the gold standard for diagnosing cardiac myeloid sarcomas.
Multiple diagnostic modalities can aid in the detection of CMS.
Early identification of CMS is critical in patients with hematologic malignancies.

Implications:

Cardiac myeloid sarcomas, though rare, require a comprehensive diagnostic strategy.
Prompt diagnosis and management are essential for patients with hematologic malignancies presenting with cardiac symptoms.
A multimodal approach ensures accurate diagnosis and guides treatment decisions for cardiac myeloid sarcomas.