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Adaptive Psychosocial Outcomes in Cancer Predisposition Syndromes: A Scoping Review
Joan W Hanania1,2,3, Kevin K Tsang3,4, Chloe Rotman5
1Department of Supportive Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Journal of Adolescent and Young Adult Oncology
|August 8, 2025
Summary
Cancer predisposition syndromes (CPSs) in children are linked to unique psychosocial challenges. This review highlights a significant gap in understanding adaptive coping strategies for young patients and their families, emphasizing the need for further research.
Area of Science:
- Genomic Medicine
- Pediatric Oncology
- Psychosocial Health
Background:
- Advances in genomic medicine increasingly link cancer predisposition syndromes (CPSs) to childhood cancers.
- Children and adolescents with CPSs experience complex medical and psychosocial issues throughout development.
- Limited understanding exists regarding the conceptualization and promotion of adaptive psychosocial outcomes for these young individuals and their families.
Purpose of the Study:
- To conduct a scoping review to describe, synthesize, characterize, and identify literature gaps on adaptive psychosocial outcomes in young people with CPSs and their caregivers.
- To explore modifiable targets in psychological care to enhance coping for patients with CPSs and their families.
Main Methods:
- Systematic literature search adhering to PRISMA Extension guidelines in PubMed, EMBASE, CINAHL, and PsycINFO (February 2024).
- Screening of 642 titles and full-text review of 36 articles.
- Inclusion of five articles meeting study criteria, predominantly descriptive studies focusing on caregivers of at-risk patients.
Main Results:
- The review identifies a substantial gap in the literature concerning adaptive psychosocial outcomes for pediatric CPS.
- Key findings include the significance of genetic testing, perceived benefits of surveillance, positive psychological outcomes, intra-family communication, and the need for psychosocial support for young people and caregivers.
- The majority of reviewed articles focused on caregivers of at-risk patients.
Conclusions:
- There is a critical need for research into adaptive psychosocial outcomes and coping mechanisms for pediatric CPS.
- Findings underscore the importance of psychological support and evidence-based interventions to promote coping in this population.
- Future research should focus on developing and disseminating psychological approaches tailored to young people with CPSs and their families.
Keywords:
adaptive psychosocial outcomescancer predisposition syndromecancer screeningcoping mechanismsgenetic counselingpediatric psycho-oncologyscoping reviewMore Related Videos
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