Related Experiment Video
Updated: Sep 12, 2025
Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis
Published on: November 10, 2023
Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice
Hannah Stocks1, Jolien Van Cleemput2, Linos Vandekerckhove3
1Cell Death Signaling Laboratory, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium; VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium.
Abstract:
Humanized mouse models with transgenic expression of human myelopoiesis-supporting growth factors have enhanced human myeloid cell engraftment and improved the study of human innate immune responses. Here, we discuss the remaining challenges associated with studying innate immunity in humanized NSG-SGM3 and MISTRG mice, as well as potential advances to overcome them.
