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The Influence of Liver Resection on Intrahepatic Tumor Growth
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Income Level and Survival After Resection of Liver Metastases: A Population-Based Study
Cecilia Strömberg1, Mirna Abraham-Nordling2,3
1Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
World Journal of Surgery
|August 9, 2025
Summary
Lower income is linked to shorter survival after colorectal cancer liver metastases resection. Younger age, less comorbidity, and female sex are associated with improved long-term outcomes in these patients.
Area of Science:
- Oncology
- Surgical Oncology
- Health Services Research
Background:
- Colorectal cancer liver metastases (LM) pose a significant challenge in cancer care.
- Socioeconomic factors' impact on long-term survival after LM resection is not fully understood.
Purpose of the Study:
- To investigate the association between socioeconomic factors and long-term survival following liver resection for colorectal cancer.
- To identify demographic and clinical risk factors influencing survival outcomes.
Main Methods:
- Retrospective nationwide population-based cohort study utilizing Swedish registries (2002-2011).
- Inclusion of patients who underwent hepatectomy for liver metastases.
- Survival analysis using Kaplan-Meier and Cox regression models to assess risk factors.
Main Results:
- A total of 2327 patients undergoing 2874 liver resections were analyzed.
- Overall 5-year survival rate was 48%.
- Multivariate analysis revealed that younger age, lower comorbidity, female sex, and higher income were significantly associated with improved overall survival (OS).
Conclusions:
- Lower income is a significant predictor of shorter overall survival in patients undergoing resection for colorectal liver metastases.
- Younger age, reduced comorbidity, and female sex are favorable prognostic factors for long-term survival.
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