Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease-Promoting Mechanisms

Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch, proprioception and visceral sensation. These mechanosensation processes, where mechanical forces are converted into electrochemical signals, are essential for sensory perception, interoception and systemic homeostasis. Critically, Piezo2 channels are fundamental to diverse physiological functions, such as skeletal growth, respiratory development and inter-organ homeostasis. Despite its established role in sensory neurons and specialised mechanotransducers, the molecular intricacy of Piezo2-mediated signalling and its pathophysiological relevance remain incompletely understood. This review highlights key evidence from recent studies employing advanced technologies supporting the potential of Piezo2 channels as vital mechanosensor that regulate mechanotransduction cascades in physiological systems, demonstrating their potential as drug targets for the development of therapeutic agents.