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Renal Function in Patients after Metabolic and Bariatric Surgery
Yuming Huang1,2,3, Yanfei Nong2, Wah Yang4
1Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Obesity Surgery
|August 9, 2025
Summary
Metabolic bariatric surgery improves kidney function post-operation, particularly in patients with hyperfiltration or chronic kidney disease (CKD). Monitoring age, hypertension, and urea levels pre-surgery is key for optimal outcomes.
Area of Science:
- Nephrology
- Bariatric Surgery
- Metabolic Health
Background:
- Obesity is a significant risk factor and accelerator for chronic kidney disease (CKD) progression.
- Metabolic bariatric surgery has demonstrated substantial benefits in managing CKD.
- Understanding the multifaceted impact of bariatric surgery on renal function is crucial.
Purpose of the Study:
- To evaluate the impact of metabolic bariatric surgery on renal function.
- To compare outcomes between Roux-en-Y gastric bypass (RYGB) and laparoscopic Sleeve Gastrectomy (LSG).
- To analyze renal function changes across different baseline GFR categories.
Main Methods:
- Analysis of 278 patients undergoing RYGB or LSG between January 2020 and May 2023.
- Patients categorized by baseline glomerular filtration rate (GFR): hyperfiltration, normal, CKD stage 2, and CKD stage 3.
- Pre- and post-operative renal function, metabolic parameters, and clinical data were compared.
Main Results:
- Post-operative GFR showed a slight increase from 115 to 118 mL/min; significant improvements in weight, glucose, lipids, and blood pressure were observed.
- Both RYGB and LSG improved renal function, with no significant difference between surgical techniques.
- Subgroup analysis revealed GFR normalization in 40.7% of hyperfiltration patients; 50% of CKD stage 2/3 patients showed improvement. Age, hypertension, and urea levels correlated with post-op GFR.
Conclusions:
- Metabolic bariatric surgery positively influences renal function one year post-operation.
- Preoperative assessment of age, hypertension, and serum urea is vital for predicting outcomes.
- Regular follow-up is essential to monitor for potential postoperative renal insufficiency.
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