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Published on: September 22, 2019
Multisystem inflammatory syndrome in children (MIS-C) with secondary intestinal cytomegalovirus infection: A case
Chunqiao Li1, Tianlei Zhang1, Youjun Xie2
1Guangxi University of Chinese Medicine, Nanning 530000, China.
Abstract:
Multisystem inflammatory syndrome in children (MIS-C) constitutes a severe pediatric disorder temporally linked to SARS-CoV-2 infection. Although SARS-CoV-2 may induce cytomegalovirus (CMV) reactivation, MIS-C cases with secondary intestinal CMV infection are exceptionally rare. We describe a pediatric patient with MIS-C treated initially with intravenous immunoglobulin (IVIG) and methylprednisolone, following clinical improvement, sudden high fever and worsening abdominal symptoms occurred. Symptomatic resolution occurred following ganciclovir administration, with CMV infection confirmed by colonic histopathology and metagenomic next-generation sequencing (mNGS).
Insights
Multisystem inflammatory syndrome in children (MIS-C) can rarely involve secondary intestinal cytomegalovirus (CMV) infection. Prompt ganciclovir treatment resolved symptoms in a pediatric patient with MIS-C and confirmed CMV colitis.
Area of Science:
- Pediatric infectious diseases
- Gastroenterology
- Virology
Background:
- Multisystem inflammatory syndrome in children (MIS-C) is a severe condition linked to SARS-CoV-2.
- Cytomegalovirus (CMV) reactivation can occur with SARS-CoV-2, but secondary intestinal CMV infection in MIS-C is rare.
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