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Related Experiment Videos

Free plasma testosterone levels during the normal menstrual cycle.

M B Mathor, S S Achado, B L Wajchenberg

    Journal of Endocrinological Investigation
    |October 1, 1985
    PubMed
    Summary

    Free testosterone levels in women fluctuate during the menstrual cycle, with unbound testosterone increasing in the luteal phase. This study examined free and total testosterone during the female menstrual cycle.

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    Area of Science:

    • Endocrinology
    • Reproductive Biology

    Background:

    • Testosterone plays a role in female physiology.
    • Understanding testosterone dynamics throughout the menstrual cycle is crucial for reproductive health.

    Purpose of the Study:

    • To measure free and total testosterone levels in normal females throughout the menstrual cycle.
    • To investigate the relationship between testosterone levels and menstrual cycle phases.
    • To compare findings with anovulatory cycles.

    Main Methods:

    • Utilized equilibrium dialysis on undiluted plasma for simplified free testosterone measurement.
    • Analyzed plasma samples from ten normal females across their menstrual cycles.
    • Evaluated two patients with anovulatory cycles for comparison.

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    Main Results:

    • Total testosterone concentration decreased progressively during the menstrual cycle.
    • Percent free testosterone increased from the follicular to the luteal phase.
    • Free testosterone levels declined significantly in the late luteal phase.

    Conclusions:

    • Female testosterone levels exhibit significant variation during the menstrual cycle.
    • Progesterone may displace testosterone from binding proteins, influencing free testosterone levels.
    • Further in vitro studies suggest progesterone's role in testosterone binding.