Aging and anti-aging strategies: A review of past and future therapeutics

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Updated: Sep 12, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

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Yuqing Wei1, Baichen Xiong1, Zuoaoyun Song1

  • 1School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Bioorganic & Medicinal Chemistry
|August 9, 2025
PubMed

Insights

This review explores anti-aging strategies targeting cellular senescence, NAD+ levels, inflammation, and proteostasis to extend lifespan and healthspan. Research highlights key pathways and agents for delaying aging and related diseases.

Area of Science:

  • Gerontology and Molecular Biology
  • Biomedical Research on Aging

Background:

  • Aging is a natural degenerative process leading to reduced physiological function and increased disease risk.
  • Identifying interventions to slow aging and improve healthspan is a critical research area.

Purpose of the Study:

  • To review current understanding of aging mechanisms and related signaling pathways.
  • To summarize advancements in anti-aging agents and strategies.
  • To discuss future directions for aging intervention research.

Main Methods:

  • Literature review of aging research, focusing on key pathways and therapeutic targets.
  • Compilation of data on emerging anti-aging agents and interventions.
  • Analysis of strategies for delaying aging and age-related diseases.

Main Results:

  • Key aging pathways include senescent cell clearance, NAD+ augmentation, anti-inflammatory/anti-oxidant defense, proteostasis, and telomerase activation.
  • Various anti-aging agents and strategies show promise in preclinical and clinical studies.
  • Interventions aim to improve lifespan and healthspan by targeting these aging mechanisms.

Conclusions:

  • Targeting specific aging pathways offers potential for therapeutic intervention.
  • Continued research into anti-aging agents and strategies is crucial for combating age-related diseases.
  • Future efforts should focus on translating research findings into effective human interventions.
Keywords:
Activation of telomeraseAgingAnti-aging strategiesAnti-oxidant defenseCellular senescenceNAD(+) augmentationTherapeutic agent

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