Cardiovascular inflammaging: Mechanisms, consequences, and therapeutic perspectives

Area of Science:

• Cardiovascular Science
• Immunology
• Gerontology

Background:

• Aging and systemic inflammation are key risk factors for cardiovascular disease.
• Inflammaging, the chronic inflammation associated with aging, exacerbates cardiovascular risks.

Purpose of the Study:

• To review the interrelationship between aging and inflammation (inflammaging).
• To explore the consequences of inflammaging on cardiovascular health.
• To discuss emerging biomarkers and therapeutic strategies for inflammaging.

Main Methods:

• Literature review summarizing current research on inflammaging and cardiovascular disease.
• Discussion of underlying mechanisms: epigenetic modification, mitochondrial dysfunction, cellular senescence, and gut dysbiosis.
• Analysis of current and potential therapeutic interventions.

Main Results:

• Inflammaging involves interrelated mechanisms contributing to cardiovascular aging.
• Biomarkers for inflammaging are increasingly recognized and incorporated into guidelines.
• Therapeutic strategies targeting inflammaging show promise for cardiovascular outcomes.

Conclusions:

• Inflammaging is a critical component of cardiovascular aging.
• Targeting inflammaging offers promising new avenues for cardiovascular disease therapies.