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Updated: Sep 12, 2025

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
Published on: April 4, 2019
Recent advances of the respiratory syncytial virus inhibitors
Zhongling Shi1, Anchao Ge1, Xin Li1
1Department of Medicinal Chemistry, Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, PR China.
Abstract:
Respiratory syncytial virus (RSV) remains a leading cause of severe lower respiratory tract infections in infants and the elderly, despite the lack of specific therapeutic drugs for treating RSV infection. This review summarizes recent structural advances in RSV drug discovery, particularly the co-crystal structures of the viral fusion (F) protein and RNA polymerase with inhibitors. By highlighting their significance in rational structure-based drug design, we hope to provide valuable insights for the development of next-generation RSV therapeutics via structure-based approaches.
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