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Updated: Sep 12, 2025

Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model
Published on: February 10, 2023
A novel technique for accessing the pericardial space
Guangxia Wang1, Huadi Qin2, Lin Hou3
1Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Cardiology, Yibin Second People's Hospital-West China Yibin Hospital, Sichuan University, Yibin, Sichuan, China.
Background:
Pericardial procedures are potentially dangerous in patients with minimal anterior pericardial effusion and cases with pericardium adhesion.
Objective:
To enhance safety, we used an innovative wire puncture technique for pericardiocentesis.
Methods:
The hard end of the percutaneous transluminal coronary angioplasty guidewire was used to puncture the parietal pericardium. To improve the puncture ability, a flat-tipped metal tube was used to support the guidewire; furthermore, a microcatheter was used to exchange the soft end of the guidewire. Before the clinical trial, the novel technique was tested in 10 pigs to evaluate its feasibility and safety.
Results:
The novel method achieved a 98.15% success rate in all 10 pigs and 54 patients with challenging pericardiocentesis, including minimal anterior effusion (5.50 ± 2.28 mm) and dry pericardiocentesis with no significant complications. The wire puncture technique also proved effective for acute iatrogenic pericardial effusion, even in pericardial adhesions.
Conclusion:
The innovative wire puncture technique is safe and feasible for challenging pericardiocentesis, even in cases with pericardial adhesions.
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