Related Experiment Video
Updated: Sep 12, 2025

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
Greater Appeal and Greater Harm? Young Adults' Preference for Menthol Versus Nonmenthol Very-Low-Nicotine Cigarettes
Amy M Cohn1, Summer Frank-Pearce2, Hoda Elmasry3
1Department of Pediatrics, The University of Oklahoma Health Sciences, Oklahoma City, Oklahoma; Tobacco Settlement Endowment Trust (TSET) Health Promotion Research Center, Stephenson Cancer Center, The University of Oklahoma Health Sciences, Oklahoma City, Oklahoma.
Introduction:
The U.S. Food and Drug Administration proposed rulemaking to reduce cigarette nicotine content and ban menthol in cigarettes. Menthol is popular among young adults who smoke, although it is unclear how this group would respond if both policies were implemented.
Methods:
A total of 112 young adults who smoke menthol cigarettes completed 3 visits that varied by cigarette smoked (2021-2024): usual brand menthol, menthol very-low-nicotine cigarette (0.3 mg nicotine/g tobacco), and nonmenthol very-low-nicotine cigarette. Very-low-nicotine cigarette flavor order was counterbalanced. Subjective response and smoking topography were assessed at each session as well as pre-post smoking measurements of expired carbon monoxide, cigarette weight, cardiovascular effects, nicotine withdrawal, and craving. Repeated-measures ANOVAs were used to examine differences in the outcomes across cigarette type.
Results:
Total smoking duration, interpuff interval, and puff count were higher for usual brand than for both very-low-nicotine cigarette smoking. Interpuff interval was higher in menthol very-low-nicotine cigarette smoking than nonmenthol. Usual brand was more appealing than both very-low-nicotine cigarettes and led to greater increases in carbon monoxide and cardiovascular effects and decreased postsmoking cigarette weight and craving compared with both very-low-nicotine cigarettes. Menthol very-low-nicotine cigarettes produced more positive subjective responses, higher carbon monoxide, and lower postsmoking cigarette weight and craving than nonmenthol.
Conclusions:
Participants preferred menthol over nonmenthol very-low-nicotine cigarettes, although very-low-nicotine cigarettes were less appealing than usual brand, overall. Despite similar topography across very-low-nicotine cigarette flavors, toxicant exposure and craving were greater and lower, respectively, after menthol than after nonmenthol very-low-nicotine cigarette smoking. Findings support the U.S. Food and Drug Administration's proposals to ban menthol cigarettes and institute market-wide reductions in cigarette nicotine content.
More Related Videos
09:30A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
Published on: January 18, 2018
06:39Electroencephalographic, Heart Rate, and Galvanic Skin Response Assessment for an Advertising Perception Study: Application to Antismoking Public Service Announcements
Published on: August 28, 2017
Related Concept Videos
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
Crossover Experiments
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.