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Related Concept Videos

Sperm Structure and Semen Composition01:22

Sperm Structure and Semen Composition

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During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
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Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Sperm Transport01:15

Sperm Transport

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The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
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Related Experiment Video

Updated: Sep 12, 2025

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
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[Sperm ultrastructure in patients with partial globozoospermia].

Hao-Ran Liu1, Liu Yang1, Hui Tian1

  • 1Central Laboratory, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, Shanxi 030012, China.

Zhonghua Nan Ke Xue = National Journal of Andrology
|August 10, 2025
PubMed
Summary

Partial globozoospermia involves sperm with abnormal morphology and ultrastructure, impacting fertility. Intracytoplasmic sperm injection (ICSI) offers a potential solution for these patients, with one case achieving pregnancy.

Keywords:
round-headed spermatozoa; sperm morphology; ultrastructure; transmission electron microscopy; intracytoplasmic single sperm injection

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Area of Science:

  • Reproductive biology
  • Human embryology
  • Andrology

Context:

  • Partial globozoospermia is a rare infertility condition characterized by a subset of round-headed sperm.
  • Understanding the morphological and ultrastructural defects is crucial for diagnosis and treatment.

Purpose:

  • To compare normal and round-headed sperm morphology and ultrastructure.
  • To evaluate assisted reproduction outcomes in patients with partial globozoospermia.

Summary:

  • Light and transmission electron microscopy revealed significant ultrastructural abnormalities in round-headed sperm, including absent acrosomes, mitochondrial dysfunction, and tail defects.
  • All six patients underwent intracytoplasmic sperm injection (ICSI), resulting in one pregnancy.
  • Morphological and ultrastructural sperm defects in partial globozoospermia are linked to infertility.

Impact:

  • This study highlights the specific ultrastructural defects in round-headed sperm contributing to infertility in partial globozoospermia.
  • Intracytoplasmic sperm injection (ICSI) demonstrates potential efficacy in overcoming infertility associated with this condition.
  • Provides insights for improved diagnostic and therapeutic strategies in male infertility.