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[Ningmitai Capsules alleviate CP/CPPS symptoms by regulating Nrf2 and NF-κB signaling pathways]
Jing-Jing Yang1,2, Nan Zhou2, Lin-Chen Lü2
1Department of Geriatric Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Zhonghua Nan Ke Xue = National Journal of Andrology
|August 10, 2025
Summary
Ningmitai Capsules (NMT) demonstrated anti-inflammatory and anti-oxidative effects in a rat model of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). NMT may work by activating the Nrf2 pathway and suppressing the NF-κB pathway.
Area of Science:
- Pharmacology
- Inflammation Research
- Urology
Context:
- Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common and debilitating condition.
- Current treatment options for CP/CPPS have limited efficacy and significant side effects.
- Understanding the underlying mechanisms of CP/CPPS is crucial for developing novel therapeutic strategies.
Purpose:
- To investigate the therapeutic effect of Ningmitai Capsules (NMT) on CP/CPPS.
- To elucidate the action mechanism of NMT in CP/CPPS.
Summary:
- A rat model of CP/CPPS was established using complete Freund adjuvant (CFA).
- Rats were treated with NMT, and their serum and prostatic tissues were analyzed for histopathological changes, inflammatory markers, oxidative stress markers, and signaling pathway activation.
- NMT treatment significantly reduced inflammation, oxidative stress, and modulated key signaling pathways (Nrf2 and NF-κB).
Impact:
- NMT exhibits significant anti-inflammatory and anti-oxidative properties relevant to CP/CPPS.
- The findings suggest NMT as a potential therapeutic agent for CP/CPPS.
- The study provides insights into the molecular mechanisms underlying NMT's efficacy, involving Nrf2 activation and NF-κB suppression.
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