Molecular Biophysics Database (MBDB) makes raw measurements findable and reusable.

Area of Science:

• Molecular Biophysics
• Biophysics
• Structural Biology

Background:

• Open science principles advocate for widespread and free access to research data.
• A lack of dedicated infrastructure hinders access to comprehensive experimental information in molecular biophysics, especially raw measurement data.
• Existing repositories do not adequately support the diverse data types generated by various biophysical methods.

Purpose of the Study:

• To introduce the Molecular Biophysics Database (MBDB) as a solution for storing and accessing raw measurement data in molecular biophysics.
• To provide a common and extensible framework for diverse biophysical data.
• To promote data reuse through comprehensive metadata compliant with FAIR principles.

Main Methods:

• Development of a common and extensible data framework for molecular biophysics.
• Implementation of data models and technologies to support raw measurement data storage.
• Integration of metadata capture aligned with FAIR data management principles.

Main Results:

• The MBDB has been established to house raw measurement data from multiple biophysical techniques.
• Currently supports bio-layer interferometry, isothermal titration calorimetry, surface plasmon resonance, and microscale thermophoresis.
• Future expansion to include additional biophysical methods is planned.

Conclusions:

• The MBDB addresses the critical need for accessible raw data repositories in molecular biophysics.
• It facilitates the principles of open science and enhances the integrity and utility of research data.
• The database provides a robust foundation for future advancements in molecular biophysics research and data sharing.