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Updated: Sep 12, 2025

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Role of P2Y6R in cancer and its antagonists

Xin Wang1, Jiliang Zhang2, Yongtao Duan3

  • 1College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.

Drug Discovery Today
|August 10, 2025
PubMed

Insights

Targeting P2Y6R (P2Y6 receptor) shows promise in cancer treatment. Blocking this receptor inhibits tumor growth, proliferation, migration, and invasion, offering a new therapeutic strategy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • P2Y6 receptor (P2Y6R) is increasingly researched for its role in various diseases.
  • Elevated P2Y6R expression correlates with tumor malignancy and metastasis.
  • P2Y6R signaling pathways are critical for cancer progression.

Purpose of the Study:

  • To review the role of P2Y6R in cancer.
  • To summarize the anticancer mechanisms of P2Y6R antagonists.
  • To highlight research progress in P2Y6R antagonist development.

Main Methods:

  • Literature review of studies on P2Y6R in cancer.
  • Analysis of P2Y6R expression in tumor tissues and cells.
  • Examination of the effects of P2Y6R antagonists on cancer cell behavior.

Main Results:

  • High P2Y6R expression is linked to increased tumor malignancy and metastasis.
  • P2Y6R antagonists effectively inhibit cancer cell proliferation, migration, and invasion.
  • Targeting P2Y6R disrupts key signaling pathways driving tumor growth.

Conclusions:

  • P2Y6R is a significant therapeutic target for various cancers.
  • P2Y6R antagonists demonstrate potent anticancer effects.
  • Further research into P2Y6R antagonists holds promise for novel cancer therapies.
Keywords:
P2Y(6)Rantagonistscancermechanism

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