Dual-ligand strategy boosted electrochemiluminescence sensing based on Tb-MOF/Ag₃PO₄@TCPP

Area of Science:

• Materials Science
• Analytical Chemistry
• Nanotechnology

Background:

• Developing sensitive detection methods for contaminants like chloramphenicol (CAP) is crucial for environmental monitoring and food safety.
• Electrochemiluminescence (ECL) sensing offers high sensitivity but requires optimized platforms for enhanced performance.
• Metal-organic frameworks (MOFs) and nanomaterials show potential in constructing advanced sensing platforms.

Purpose of the Study:

• To construct a novel ECL sensing platform using a dual-ligand strategy for sensitive CAP detection.
• To investigate the role of dual-ligand terbium-based MOF (Tb-MOF) and silver phosphate@tetracarboxyphenyl porphyrin (Ag3PO4@TCPP) in enhancing ECL signals.
• To explore the potential applications of this platform in environmental monitoring and food safety.

Main Methods:

• A dual-ligand strategy was employed to synthesize a Tb-MOF/Ag3PO4@TCPP composite material.
• The composite was utilized to construct an ECL sensing platform for CAP detection.
• Electrochemiluminescence (ECL) and electron spin resonance (ESR) spectroscopy were used to study the ECL mechanism.

Main Results:

• The dual-ligand Tb-MOF acted as a co-reactant promoter, enhancing the electroreduction of S2O8(2-) and boosting the luminescence of Ag3PO4@TCPP.
• The Ag3PO4@TCPP emitter effectively mitigated the aggregation-caused quenching (ACQ) effect of TCPP, increasing luminescence intensity seven-fold.
• The developed ECL biosensor exhibited a wide linear range (10^-6 to 10^-15 M) and a low detection limit (8.29 x 10^-16 M) for CAP.

Conclusions:

• The dual-ligand strategy effectively enhances ECL signals, providing a high-performance sensing platform.
• The developed Tb-MOF/Ag3PO4@TCPP system demonstrates significant potential for sensitive and reliable CAP detection.
• This study expands the application scope of dual-ligand lanthanide MOFs in sensing technologies.