Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

3.3K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
3.3K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

67
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
67
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

91
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
91
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

6.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nudging Nephrologists in Cardiovascular Risk Assessment and Management in Glomerular Diseases Treated with Immunosuppressants: An Implementation Study.

Glomerular diseases·2026
Same author

Long-term incidence and progression of vision-threatening diabetic retinopathy in Asian populations.

Journal of global health·2026
Same author

Multi-Marker Detection of Diabetic Kidney Disease and Risk of Incident Diabetic Retinopathy in a Multi-Ethnic Asian Population.

Diagnostics (Basel, Switzerland)·2026
Same author

Pattern of association between school grades and myopia: longitudinal findings from the SCORM cohort.

Eye (London, England)·2026
Same author

Retinal biological age correlates with bone mineral density and fracture risk score and predicts incident osteoporosis.

PLOS digital health·2026
Same author

Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals.

Nature medicine·2026

Related Experiment Video

Updated: Sep 12, 2025

Retinal Pathophysiological Evaluation in a Rat Model
09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

4.7K

Retinal Neuronal Changes and Kidney Dysfunction in Diabetes Mellitus.

Dan Cao1,2, Qianhui Yang1,3, Yueheng Hong1

  • 1Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Clinical & Experimental Ophthalmology
|August 11, 2025
PubMed
Summary
This summary is machine-generated.

Outer plexiform layer (OPL) thickening in the retina may indicate diabetic kidney disease (DKD). Optical coherence tomography (OCT) can noninvasively assess this link, potentially aiding in DKD monitoring.

Keywords:
diabetic kidney diseasediabetic retinopathyestimated glomerular filtration rateoptical coherence tomographyouter plexiform layer

More Related Videos

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish
05:49

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish

Published on: May 5, 2021

5.0K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

281

Related Experiment Videos

Last Updated: Sep 12, 2025

Retinal Pathophysiological Evaluation in a Rat Model
09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

4.7K
Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish
05:49

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish

Published on: May 5, 2021

5.0K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

281

Area of Science:

  • Ophthalmology and Nephrology
  • Diabetic Complications
  • Biomarker Discovery

Background:

  • Diabetic kidney disease (DKD) and diabetic retinopathy (DR) share microvascular pathologies.
  • The link between retinal neuronal changes and kidney dysfunction in diabetes is not fully understood.
  • Identifying novel biomarkers for DKD is crucial for early detection and management.

Purpose of the Study:

  • To investigate the association between individual retinal layer thickness and kidney function indicators in type 2 diabetes (T2D) patients.
  • To explore optical coherence tomography (OCT) as a tool for identifying potential biomarkers for DKD.
  • To determine if retinal neuronal alterations correlate with markers of kidney damage.

Main Methods:

  • Cross-sectional study of 410 T2D patients (815 eyes).
  • Retinal layer thickness measured using OCT with automated segmentation.
  • Generalized Estimating Equation (GEE) analysis correlated retinal thickness with estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) categories.

Main Results:

  • Significant association found between outer plexiform layer (OPL) thickness and both eGFR and UACR categories.
  • Perifoveal OPL thickness showed the strongest inverse association with eGFR and positive association with UACR.
  • The association remained significant in eyes without macular edema, indicating robustness.

Conclusions:

  • Outer plexiform layer (OPL) thickening is a potential indicator for diabetic kidney disease (DKD).
  • Optical coherence tomography (OCT) provides a noninvasive method to study retinal-kidney interactions in diabetes.
  • Further longitudinal studies are warranted to confirm the utility of OPL thickness in monitoring DKD progression.