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Case Report: Overlapping Rheumatoid Arthritis and Systemic Sclerosis in an Elderly Male With Positive Fibrillarin
Lina An1, Jian Lu2, Chang Liu1
1Department of Rheumatology and Immunology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
International Journal of Rheumatic Diseases
|August 11, 2025
Summary
This case report details a rare overlap syndrome of rheumatoid arthritis and systemic sclerosis (RA-SSc) in a patient positive for fibrillarin autoantibodies. Treatment improved joint symptoms, suggesting fibrillarin
Area of Science:
- Rheumatology
- Immunology
- Autoimmune Diseases
Background:
- Overlap syndrome of rheumatoid arthritis (RA) and systemic sclerosis (SSc) is uncommon.
- Fibrillarin autoantibodies are associated with systemic sclerosis, particularly the nucleolar P0 (N0-120) antigen.
Observation:
- A 67-year-old male presented with confirmed RA-SSc overlap syndrome.
- The patient was positive for fibrillarin autoantibodies.
Findings:
- Therapeutic intervention with methylprednisolone, methotrexate, and adjuvant medications led to significant improvement in articular symptoms.
- This case highlights the diagnostic and prognostic value of fibrillarin autoantibodies in SSc.
Implications:
- Fibrillarin autoantibody positivity may aid in diagnosing and predicting outcomes in SSc.
- The co-occurrence of RA-SSc overlap syndrome and fibrillarin autoantibody positivity is rare and warrants further investigation.
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