An In-Depth Study of Circular RNAs Related to Breast Cancer Treatment and their Implications

Circular RNAs, or circRNAs, play a key role in breast cancer biology, directly impacting the diagnosis, prognosis, and treatment of the disease. This review explores the mechanisms, regulatory roles, and functional significance of circRNAs in breast cancer. Overexpressed circRNAs regulate gene expression, cell cycle progression, and drug response in breast cancer. This process is facilitated by the interaction between small RNA molecules (miRNAs) and proteins that can bind to RNA (RBPs), which target the main messenger RNA (mRNA). Consequently, they influence gene expression, cellular proliferation, and drug resistance. Dysregulated circRNA expression contributes to breast cancer progression by promoting tumor aggressiveness and treatment resistance.