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Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
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Combined Inductive and Dispersion Effects Enhance Bioorthogonal Reactivity of Tetrazines Toward Isonitriles

Suprakash Biswas1, Andreas Löffler2, Pushkar Bansal3

  • 1Department of Medicinal Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, UT, 84112, USA.

Angewandte Chemie (International Ed. in English)
|August 11, 2025
PubMed

Keywords:
Bioorthogonal chemistryChemoselectivityCycloadditionDensity functional calculationsIsonitriles

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