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Lifetime Cannabis Use and Incident Hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Jamie Corroon1, Ryan Bradley2, Igor Grant1

  • 1Center for Medicinal Cannabis Research, Department of Psychiatry (J.C., I.G.), University of California, San Diego.

Hypertension (Dallas, Tex. : 1979)
|August 11, 2025
PubMed

Insights

This study found no significant link between cumulative lifetime cannabis use and the risk of developing hypertension over 35 years. These findings suggest cannabis use does not increase hypertension risk in young adults.

Area of Science:

  • Cardiovascular Health
  • Epidemiology
  • Substance Use Research

Background:

  • Observational studies on cannabis use and hypertension show inconsistent results.
  • Existing research lacks comprehensive long-term data on this association.

Purpose of the Study:

  • To investigate the association between cumulative lifetime cannabis use and incident hypertension.
  • To analyze this relationship over a 35-year period in young adults.

Main Methods:

  • Utilized data from the Coronary Artery Risk Development in Young Adults (CARDIA) study.
  • Employed marginal structural models with inverse probability weighting to adjust for confounding factors.
  • Conducted Cox proportional hazards regression and sensitivity analyses.

Main Results:

  • Analyzed 4328 participants over 35 years, with 2810 completing follow-up.
  • Found no significant association between cumulative cannabis use (cannabis-years) and incident hypertension (aHR, 0.99; 95% CI, 0.97-1.00).
  • Sensitivity analyses confirmed the robustness of these findings.

Conclusions:

  • No association was observed between cumulative lifetime cannabis use and the risk of developing hypertension in a diverse cohort.
  • Findings remained consistent across various analytical approaches and subgroup analyses.
  • This study contributes robust long-term evidence regarding cannabis use and cardiovascular health.
Abstract

Keywords:
blood pressurecannabiscardiovascular diseaseshypertensionmarijuana

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