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Updated: Sep 11, 2025
Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Eradication of Helicobacter pylori: challenges and advances
Yousra Sbibih1,2, Abderrazak Saddari1,2, Ilham Alla1,2
1Laboratory of Microbiology, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, Morocco.
Background And Objectives:
Helicobacter pylori, identified in 1982, remains a major cause of gastric infections. Despite extensive research, an ideal treatment regimen for its eradication is yet to be determined, with antibiotic resistance posing a significant challenge. This study, conducted at Mohammed VI University Hospital, aimed to evaluate and compare the effectiveness of different therapeutic protocols for H. pylori eradication.
Materials And Methods:
This 13-month retrospective descriptive study was conducted at the Microbiology Laboratory of Mohammed VI University Hospital in Oujda, Morocco, to evaluate patients suspected of H. pylori infection using the urea breath test.
Results:
A total of 190 patients were included, with an overall eradication rate of 73%. Three therapeutic protocols were tested, and bismuth concomitant therapy showed the highest eradication rate at 82%, outperforming the other regimens.
Conclusion:
These findings highlight the importance of combining antimicrobial agents with antisecretory treatments to enhance eradication outcomes. The study also emphasizes the need for novel treatment strategies, particularly in light of rising antibiotic resistance. Vonoprazan-based regimens appear to offer a promising alternative, especially in the absence of antibiotic sensitivity testing. Future research should focus on optimizing treatment protocols while preserving beneficial gut flora.
Insights
Bismuth concomitant therapy achieved the highest eradication rate for Helicobacter pylori infections at 82%. This highlights the importance of combination therapies in combating antibiotic resistance for gastric health.
Area of Science:
- Gastroenterology
- Microbiology
- Infectious Diseases
Background:
- Helicobacter pylori remains a significant cause of gastric infections globally.
- Antibiotic resistance complicates H. pylori eradication, necessitating optimized treatment strategies.
Purpose of the Study:
- To evaluate and compare the effectiveness of different therapeutic protocols for H. pylori eradication.
- To identify optimal treatment regimens in a Moroccan population.
Main Methods:
- A retrospective descriptive study involving 190 patients suspected of H. pylori infection.
- Utilized the urea breath test for diagnosis and evaluated three distinct therapeutic protocols.
Main Results:
- An overall H. pylori eradication rate of 73% was achieved.
- Bismuth concomitant therapy demonstrated the highest eradication rate at 82%.
Conclusions:
- Combination therapy, including antimicrobial agents and antisecretory treatments, enhances eradication outcomes.
- Vonoprazan-based regimens show promise, especially without antibiotic sensitivity testing, to address rising antibiotic resistance.
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