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Decrease in Vitamin D Binding Protein in Acute Fractures Does Not Affect Vitamin D Levels.

Ji Sup Hwang1, Siew Khei Liew2, Kyu Tae Kim3

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|August 11, 2025
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Acute musculoskeletal injuries, like wrist fractures, lower vitamin D binding protein (VDBP) levels. However, these changes did not impact vitamin D levels in patients, suggesting current measurements may not fully reflect vitamin D status.

Keywords:
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Area of Science:

  • Biochemistry
  • Endocrinology
  • Orthopedics

Background:

  • Vitamin D binding protein (VDBP) transports vitamin D (VD) and its levels fluctuate with inflammation.
  • Systemic inflammation is known to alter VDBP levels.
  • The impact of acute musculoskeletal injury on VDBP and VD levels remains unclear.

Purpose of the Study:

  • To investigate the effect of acute musculoskeletal injury on VDBP levels.
  • To determine if VDBP level changes impact vitamin D status following injury.
  • To compare VDBP and vitamin D levels in patients with wrist fractures versus healthy controls.

Main Methods:

  • Serum VDBP, free 25(OH)D, and total 25(OH)D were measured.
  • Two age-matched female groups were studied: wrist fracture patients (n=35) and healthy volunteers (n=35).
  • Statistical analysis compared groups and assessed correlations between measurements.

Main Results:

  • VDBP levels were significantly lower in the wrist fracture group compared to healthy volunteers (p < 0.001).
  • Free and total 25(OH)D levels did not differ significantly between the groups.
  • Correlation between free and total 25(OH)D was strong in healthy controls (R=0.885) but moderate in fracture patients (R=0.605).

Conclusions:

  • Acute musculoskeletal injuries lead to decreased VDBP levels.
  • Reduced VDBP levels post-injury did not alter free or total vitamin D levels.
  • Further research is needed to ascertain if total 25(OH)D accurately reflects VD status in fracture patients.