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Updated: Sep 11, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
The role of gut microbiota in insulin resistance: recent progress
Hongfang Ji1, Shenglin Su2, Min Chen1
1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Abstract:
Insulin resistance (IR) is the most critical pathophysiological basis of type 2 diabetes mellitus (T2DM). The mechanisms underlying IR are extremely complex, with variations observed among different patients and different tissues. Current research has gradually revealed characteristics of the gut microbiota and its role in metabolizing major nutrients during IR. The interaction between microbial communities and host metabolism has become a hotspot in modern medical research. This review aims to provide a comprehensive understanding of microbial metabolism related to IR by elucidating the effects of microbiota-carbohydrate metabolism and microbiota-host interactions on IR. Such insights may contribute to improving IR and offer novel perspectives for its treatment.
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